A vaso-occlusive crisis (VOC) can transform a normal day into a medical emergency for sickle cell patients. This condition happens when sickle-shaped red blood cells clump together and block blood vessels. While the exact cause is unknown, medical experts have identified several triggers that can precipitate these dangerous episodes, making it vital for patients and their families to recognize the warning signs and understand the potential risk factors. If your VOC was caused by a dangerous drug, contact the Oxbryta injury lawyer at Shapiro Legal Group, PLLC at once for assistance.
Symptoms of a Vaso-Occlusive Crisis
A VOC develops when your abnormally shaped red blood cells become trapped in small blood vessels, creating blockages that restrict blood flow throughout your body. This process can occur gradually over hours or days, starting with mild discomfort that escalates into severe complications requiring immediate medical attention.
The symptoms you might experience during a VOC include:
- Excruciating bone pain, especially in your back, legs, knees, arms, chest, or abdomen
- Chest pain accompanied by difficulty breathing or shortness of breath
- Major anemia that leaves you feeling weak and exhausted
- Dangerous drops in blood pressure that can lead to dizziness or fainting
- Loss of consciousness or an altered mental state
- Yellowing of your skin, eyes, or the inside of your mouth
- Signs of severe organ damage, including stroke symptoms
Possible Triggers for Vaso-Occlusive Crises
Dehydration
When your body lacks adequate fluids, your blood becomes more concentrated and viscous, which may make it easier for sickle cells to stick together and form dangerous clots. Some experts believe that even mild dehydration from hot weather, exercise, or insufficient water intake has the potential to trigger a crisis.
Infections
Your immune system’s response to bacterial, viral, or other infections may stress your body and trigger sickling of red blood cells. Common conditions like pneumonia, urinary tract infections, or even the flu can precede a VOC.
Stress
All forms of stress have the potential to trigger vaso-occlusive episodes. Physical stressors might include surgery, injury, or extreme fatigue, while emotional stress from work, relationships, or major life changes may also initiate a crisis.
Cold Temperatures
Exposure to cold weather or environments can cause your blood vessels to constrict, reducing circulation. Some experts believe that the cold may make it easier for sickle cells to become trapped and trigger a VOC.
Certain Medications
Some medications can increase your risk of developing a VOC by affecting blood flow, oxygen levels, or red blood cell behavior. For example, Pfizer recently withdrew its sickle cell drug Oxbryta after clinical data revealed that the medication was associated with an increased risk of vaso-occlusive crises and other serious complications.
What to Do If You Notice Signs of a VOC
Although no one knows for sure what causes a VOC, one fact is certain: a VOC is a medical emergency. If you notice any unusual symptoms, seek immediate care. Early intervention can prevent complications and reduce the severity of your symptoms. Contact your healthcare provider or go to the nearest emergency room, especially if you experience severe pain, difficulty breathing, or signs of organ dysfunction.
Did You Experience a VOC While Taking Oxbryta?
VOCs can disrupt your life and cause painful, debilitating symptoms. Oxbryta, a medication used to treat sickle-cell disease, may trigger these episodes in the very patients it was created to protect. If you were diagnosed with a VOC while taking Oxbryta, Shapiro Legal Group, PLLC can help you hold the manufacturer accountable. Contact us at (212) 485-9899 to explore your legal options and begin your journey to justice.